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Name: do i have to stay on semaglutide forever Weight-loss drugs like Wegovy are meant for long-term use. What happens if you stop?
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SURPASS-2 (NEJM 2021) was the definitive head-to-head: tirzepatide vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions.

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